Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia
Figure 3
Effects of digitoxin on DNA synthesis in leukaemic cell lines.
Effects of digitoxin exposure on DNA synthesis (i.e. thymidine incorporation) in CCRF-CEM (A) and SUP-B15 (B) cells. The DNA polymerase inhibitor aphidicolin (15 µM) was used as a positive control. Effects of digitoxin exposure on protein synthesis (i.e. leucine incorporation) in CCRF-CEM (C) and SUP-B15 (D) cells. The ribosomal inhibitor cycloheximide (36 µM) was used as a positive control.