Classification of Drugs Based on Properties of Sodium Channel Inhibition: A Comparative Automated Patch-Clamp Study
Figure 4
Dependence of properties of inhibition on specific chemical properties.
Drugs belonging to different types of inhibition are shown in different colors. For values of individual drugs see Table 2, Table 3 and Results S6. Biophysical properties plotted against chemical descriptors. A)–C): logP, D)–F): logD7.3, G)–I): aromatic atom count, J)–M): logN(pKa), N)–P): minimal projection area. Regression lines and correlation coefficients (R) are only shown where the correlation was significant (p<0.01).