Endothelium-Based Biomarkers Are Associated with Cerebral Malaria in Malawian Children: A Retrospective Case-Control Study
Figure 1
Endothelial biomarkers are associated with retinopathy (CM-R) in children with clinically defined cerebral malaria.
Graphs showing the median and scatter of plasma biomarkers (A) Ang-2 (ng/mL), (B) Ang-1(ng/mL), (C) Ang-2:Ang-1, (D) VWF propeptide (VWFpp, mmol/L), (E) VWF (mmol/L), (F) sTie-2 (ng/mL), (G) sICAM-1 (ng/mL), (H) VEGF (ng/mL) and (I) IP-10 (ng/mL) levels in retinopathy negative cerebral malaria (CM-N) or retinopathy positive cerebral malaria (CM-R) as measured by ELISA (Mann-Whitney). ns (not significant, p>0.05), *p<0.05 after Holms correction for multiple comparisons (9 pair-wise comparisons). The limit of detection is represented by a dotted line (VEGF).