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Fiber Type Conversion by PGC-1α Activates Lysosomal and Autophagosomal Biogenesis in Both Unaffected and Pompe Skeletal Muscle

Figure 5

Induction of lysosomal biogenesis in converted fibers from the tgKO.

(a) Single muscle fibers were stained for LAMP-1. The position of lysosomes in the converted type II fibers from tgKO is similar to those in type I fibers. Bar: 10 µm. (b) Western blotting of protein lysates from gastrocnemius (fast) muscles from WT, KO, and tgKO mice with LAMP-1 and cathepsin D antibodies showing increased levels of two lysosomal proteins. Two WT, six KO and six tgKO mice were analyzed.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0015239.g005