Regulation of Muscle Satellite Cell Activation and Chemotaxis by Angiotensin II
Figure 1
Inhibition of Ang II signaling abrogates skeletal muscle growth following CTX injury.
Representative H&E stains of TA cross-sections of (A) control and (B) captopril treated mice 21 days after CTX injection (both photos - 40x magnification). C) Mean muscle fibre CSA of control and captopril treated mice 10 and 21 days following CTX injection. Note: ◊ - indicates CSA of uninjured mice (n = 6 per group). D) Distribution of small (<1500 µm2), medium (1500–3000 µm2) and large (>3000 µm2) size muscle fibres of control and captopril treated mice 21 days following CTX injection. E) Analysis of muscle fibre CSA of control and AT1a−/− mice 7, 14 and 21 days following CTX injection (n = 4 per group). Data are presented as mean ± s.e.m, *indicates a significant difference (p<0.05) from control.