Genetic and Functional Analysis of the DLG4 Gene Encoding the Post-Synaptic Density Protein 95 in Schizophrenia
Figure 3
Reporter gene activity assays of molecular variants of the DLG4 investigated in this study.
(A) The promoter activity of the C-D-C-C that is associated with schizophrenia had significantly lower than that of the C-I-T-T haplotype. I: indicates two copies of the “gcgtcctgcacgccc”of the rs6145976; D: indicates single copy of the “gcgtcctgcacgccc” of the rs6145976. (B) The T allele of the rs13331 at 3′UTR that is borderline associated with schizophrenia had significantly lower activity than that of the C allele.