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Multiscale Modelling of Vascular Tumour Growth in 3D: The Roles of Domain Size and Boundary Conditions

Figure 10

Multi-vessel basic vascular unit simulations.

A–C) Simulations in a domain are compared to a domain for each combination of boundary conditions. We find that the domain size has only a weak effect, but the choice of boundary conditions makes a significant difference to the long term tumour cell and vessel volume fractions. The most efficient vascular network can be formed on the doubly-periodic domain, while we get the least efficient network for the non-periodic boundary conditions. B) and D) show the long-time values with 95% confidence intervals.

Figure 10

doi: https://doi.org/10.1371/journal.pone.0014790.g010