Proteasome Inhibition Represses Unfolded Protein Response and Nox4, Sensitizing Vascular Cells to Endoplasmic Reticulum Stress-Induced Death
Figure 2
Activity of 20S proteasome in VSMC at control condition or after incubation with AngII (200 nM) or Tn (5 µg/mL), in the absence or presence of MG132 (1 µM) during 4 (A) or 16 (B) hours.
Cell lysates were incubated with probe AMC (LLVY-AMC) in the presence of SDS and fluorescence release followed over 15–30 min (excitation 355 nm, emission 460 nm). Data are mean ± SD of 4 or more independent experiments.*P<0.05 vs. Control. #P<0.05 vs. Tn.