Osteopontin Is Required for the Early Onset of High Fat Diet-Induced Insulin Resistance in Mice
Figure 1
Adipose tissue OPN RNA levels are elevated in obese rats and humans and are suppressed by pioglitazone treatment.
(A) Epididymal white adipose tissue OPN RNA levels from Zucker lean, obese, and pioglitazone-treated obese rats. 6 rats per group. (B) Subcutaneous white adipose tissue OPN RNA levels in lean subjects with normal insulin sensitivity and obese subjects with insulin resistance, before (black bars) and after (grey bars) pioglitazone treatment. 4–7 subjects per group. Values are averages ± standard error. * p<0.05 vs lean; # p<0.05 vs obese, before treatment. (C) Correlation between baseline adipose tissue OPN RNA levels and Rd in lean (filled symbols) and obese subjects (open symbols).