Determinants of Glycan Receptor Specificity of H2N2 Influenza A Virus Hemagglutinin
Figure 5
Glycan receptor-binding specificity of mutant forms of CkPA04 HA.
Shown in the figure is the dose-dependent glycan receptor binding (A, C, E) and human tissue binding (B, D, F) of CkPA04-LS, CkPA04-TLS and CkPA04-RTLS mutants respectively. All the mutants show substantial improvement in the human receptor binding and reduction in avian receptor binding in comparison to the WT CkPA04 HA as observed in both the glycan array tissue-binding experiments.