Genetic Evidence for Inhibition of Bacterial Division Protein FtsZ by Berberine
Figure 5
Effect of expressed antisense RNA-mediated ftsZ silencing on E. coli growth and susceptibility to berberine.
(A) Growth curves for the SOS-negative strains carrying the control and anti-ftsZ plasmids. Antisense expression was induced by a range of IPTG concentrations (0–70 µM) and cells were treated with the indicated concentrations of berberine. (B) Regression analysis of IPTG concentration and the MIC of berberine in both strains.