Nitrate Respiration Protects Hypoxic Mycobacterium tuberculosis Against Acid- and Reactive Nitrogen Species Stresses
Figure 4
ATP and nitrite production in the presence of exogenous nitrate.
M. tuberculosis viability (A), ATP production (B), membrane potential (C) and nitrite production (D) were assessed under hypoxic conditions at neutral (6.6) or mild acidic (5.5) pH, in the presence (black bar) or absence (open bar) of 20 mM nitrate after 4 and 10 days incubation period. Results are expressed as the means ± SD of triplicates. RLU, relative luminescence units; MFI, Mean fluorescence intensity. *, p<0.005.