Profound Depletion of HIV-1 Transcription in Patients Initiating Antiretroviral Therapy during Acute Infection
Figure 5
Viral nucleic acid expression in acute and chronic patients during cART.
Mean levels of vDNA (grey symbols) and UsRNA (blue symbols) (A) or viral transcription rates (B) of patients that had initiated cART during acute infection (acute, n = 24, circles) were assessed during the on-cART time window (≥24 weeks) and compared to single measurements in patients that had initiated cART during chronic infection (chronic, n = 15, triangles, median treatment time 50 weeks, range 36–183, see Table S1 for details). Data-points within the grey horizontal areas show PCR-negative samples below the detection limit of the assays applied. P-values within panels show significance levels (Mann-Whitney test) between the acute and the chronic group. Bars show medians and quartiles.