Casein Kinase 2 Dependent Phosphorylation of Neprilysin Regulates Receptor Tyrosine Kinase Signaling to Akt
Figure 7
Model for the role of NEP phosphorylation in Akt signalling.
PI3K is recruited to RTKs upon stimulation with specific ligands and phosphorylates PIP2 to PIP3. A, Non-phosphorylated NEP interacts with PTEN that antagonizes PI3K by the dephosphorylation of PIP3 to PIP2 resulting in the decreased Akt activation. B, The phosphorylation of NEP inhibits recruitment of PTEN to the plasma membrane and thereby stabilizes the pool of PIP3. Thus phosphorylation of NEP could increase or prolong the activation of Akt.