Identification of Methylated Genes Associated with Aggressive Bladder Cancer
Figure 4
Bisulfite pyrosequencing demonstrates that extent of methylation is associated with tumor grade in non-invasive tumors.
The mean (filled circle) and 95% confidence intervals of the extent of methylation of the promoter regions of (A) FRZB, (B) KRT13, and (C) HOXB2 are depicted (y-axis) comparing low (1,2) to high (3+) grade tumors (x-axis). P-values resulting from the Wilcoxon Rank Sums demonstrate that these differences are significant for HOXB2 (P<0.01), KRT13 (P<0.01) and FRZB (P = 0.0001).