Prospectively Isolated Cancer-Associated CD10+ Fibroblasts Have Stronger Interactions with CD133+ Colon Cancer Cells than with CD133− Cancer Cells
Figure 4
Invasiveness of CD133+ and CD133− HCT116 cells cocultured with fibroblasts transfected with control or CD10-targeting siRNAs.
Knockdown of CD10 expression in CD10+ fibroblasts remarkably reduces the invasiveness of cocultured CD133+ HCT116 cancer cells (P<0.001), but has a limited effect on the invasiveness of CD133− cancer cells. Representative photographs (upper panels) and graphs (lower panel) are shown. Scale bars = 100 µm.