Defining the Functional Domain of Programmed Cell Death 10 through Its Interactions with Phosphatidylinositol-3,4,5-Trisphosphate
Figure 3
Proposed PtdIns(3,4,5)P3 binding site and dimeric interface.
A. Ribbon model of PDCD10 showing the proposed PIP binding Lys residues. B. Surface-potential model of PDCD10 showing the surface positive potential charge area (blue) and negative potential charge area (red). C. Superimposition of the ribbon model and the surface-potential model. Note the proposed PIP binding Lys residues. D. Superimposition of the ribbon model and the surface-potential model shows the potential dimeric interface. Note that the dimeric interaction surfaces are mutually exclusive to the PIP binding site.