Transforming Growth Factor Beta 2 and Heme Oxygenase 1 Genes Are Risk Factors for the Cerebral Malaria Syndrome in Angolan Children
Figure 1
Association tests and LD analysis in the TGFB2 gene single-nucleotide polymorphisms (SNPs).
The diagram represents in the vertical axis, the log10 of the P value of association tests of SNPs listed in the y-axis, obtained from logistic regression analysis. The points in red, blue and green represent the results of the association with the SNPs between cases of cerebral malaria (CM) and controls with severe no cerebral malaria (SnC), uncomplicated malaria (UM) and uninfected (UIF), respectively. The upper diagram shows a scale representation of the structure of the TGFB2 gene: exons are represented by boxes and marked with its number. The bottom of the diagram represents the LD between a pair of SNPs measured by r2. The image, below and to the left, corresponds to the color scale representing the values of LD, from yellow (r2 = 0) to red (r2 = 1). This diagram is an adaptation of the figure produced by the snp. plotter R package.