Binding-Site Assessment by Virtual Fragment Screening
Figure 3
Conformational changes in IL-2.
(A) IL-2 holo conformation bound with the co-crystallized ligand FRH (1py2). (B) The same ligand is superimposed on the apo conformation of the protein (1z92), highlighting the conformational changes. Molecular images were generated with UCSF Chimera [42].