Oligomeric Interfaces Under the Lens: Gemini
Figure 5
Interfaces of the trimeric membrane protein Tol C (PDB code: 1EK9).
A. x-ray structure of TolC [47]. The three monomers are indicated in three different colors. This protein contains both α- and β- interfaces. The α-region is composed of chemical bonds between residues 13 to 39 of chain A and residues 295 to 321 of chain G. The β-region is composed of residues 40 to 57 of chain A and residues 278 to 294 of chain G. B. Interaction Networks of the α-region (left) and of the β-region (right). The “a” to “g” heptad repeat [48], which is conventionally used to describe α-coil interfaces, is reported on the segments. C. The 3D structure of the α-region. Some of the amino acids forming knobs-into-holes are indicated in balls and sticks. They are colored using blue and green for chains A and B, respectively. D. The 3D structure of the β-region. The amino acids involved in chemical bonds are indicated in balls and sticks. The images are generated using Rasmol. The symbols are described in Figure 3 and in methodology.