Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice
Figure 2
Inducing LTP in area CA1 in APPPS1-21 mice or littermate wild type controls aged 4.5 months showed robust LTP that lasted for 1 h post-HFS (n = 8 per group).
A 2-way repeated measures ANOVA did not show a difference between genotypes but over time (p<0.0001). Below: Shown are typical field fEPSPs of recordings 5 min before (1) and 1 h after HFS (2).