Prolonged Graft Survival in Older Recipient Mice Is Determined by Impaired Effector T-Cell but Intact Regulatory T-Cell Responses
Figure 6
Regulatory T-cell function remains unaltered with age.
Regulatory T-cell function remains age-independent: CD4+CD25− T-cells (responder cells) and regulatory T-cells (FoxP3+) were co-cultured at different ratios in the presence of stimulator cells. The proliferation of responder cells was determined by Thymidine incorporation. Young and old Tregs suppressed the proliferation of responder cells in a dose-dependent manner. Co-culture of old Tregs with young responders cells demonstrated a well-preserved suppressor function of old regulatory T-cells comparable to the suppressor function of young regulatory T-cells.