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Opiate-Induced Suppression of Rat Hypoglossal Motoneuron Activity and Its Reversal by Ampakine Therapy

Figure 2

Local application of DAMGO to the XII nucleus depresses inspiratory burst amplitude, area and duration.

A) ∫XII nerve activity recorded from a medullary slice preparation demonstrating that local application of DAMGO (5 µM, 30s) into the XII nucleus decreases inspiratory burst amplitude. B) Group data (n = 5) show that local application of DAMGO (5 µM, 30 s) significantly reduces XII inspiratory burst amplitude, area and duration. C) ∫XII nerve activity recorded from a medullary slice preparation demonstrating that local application of DAMGO (5 µM, 10s) into the preBötC decreases inspiratory burst amplitude and frequency. D) Group data (n = 10) show that local application of DAMGO (5 µM, 10 s) significantly reduces XII inspiratory burst amplitude and frequency. * = significantly different from control (p<0.05).

Figure 2

doi: https://doi.org/10.1371/journal.pone.0008766.g002