Opiate-Induced Suppression of Rat Hypoglossal Motoneuron Activity and Its Reversal by Ampakine Therapy
Figure 2
Local application of DAMGO to the XII nucleus depresses inspiratory burst amplitude, area and duration.
A) ∫XII nerve activity recorded from a medullary slice preparation demonstrating that local application of DAMGO (5 µM, 30s) into the XII nucleus decreases inspiratory burst amplitude. B) Group data (n = 5) show that local application of DAMGO (5 µM, 30 s) significantly reduces XII inspiratory burst amplitude, area and duration. C) ∫XII nerve activity recorded from a medullary slice preparation demonstrating that local application of DAMGO (5 µM, 10s) into the preBötC decreases inspiratory burst amplitude and frequency. D) Group data (n = 10) show that local application of DAMGO (5 µM, 10 s) significantly reduces XII inspiratory burst amplitude and frequency. * = significantly different from control (p<0.05).