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Orexin-1 Receptor Co-Localizes with Pancreatic Hormones in Islet Cells and Modulates the Outcome of Streptozotocin-Induced Diabetes Mellitus

Figure 10

Glucose tolerance test in control or streptozotocin (STZ)-treated OX−/− and C57BL/6 mice.

The graph shows blood glucose levels in control or STZ-treated OX−/− and C57BL/6 mice 0, 30, 60 and 180 min after intra-peritoneal glucose challenge (3 g/kg body weight, given intra-peritoneally). Blood glucose levels of control OX−/− and C57BL/6 mice were similar at time 0, 30, 60, 180 min. Note that blood glucose level of STZ-induced diabetic OX−/− mice was slightly but not significantly lower than that of diabetic C57BL/6 mice at 0 min. Diabetic OX−/− mice displayed a significantly (p<0.01) lower blood glucose levels compared to those of diabetic wild type at 60 and 180 min after glucose load.

Figure 10

doi: https://doi.org/10.1371/journal.pone.0008587.g010