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Substantial Contribution of Submicroscopical Plasmodium falciparum Gametocyte Carriage to the Infectious Reservoir in an Area of Seasonal Transmission

Figure 1

The relationship between Pfs25 QT-NASBA gametocyte density and the proportion of infected mosquitoes in membrane feeding experiments.

The solid line indicates the best fitted line (Y = 0.0176Ln(X) + 0.0187; R2 = 0.153). The dashed line indicates the estimated microscopic threshold for gametocyte detection, 8 gametocytes/µL, when screening 100 high power fields (i.e. ∼1000 white blood cells).

Figure 1

doi: https://doi.org/10.1371/journal.pone.0008410.g001