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Positive Regulatory Control Loop between Gut Leptin and Intestinal GLUT2/GLUT5 Transporters Links to Hepatic Metabolic Functions in Rodents

Figure 9

Release of leptin in gastric juice in response to oral load of fructose or galactose.

Changes in the amount of leptin released in the gastric juice and in plasma in mice fasted overnight and receiving an oral load of saline (CTRL), fructose [Fruct. 2 g/kg)], galactose (Gal. 6 g/kg) or intraperitoneal injection of 10 ng/g CCK-8. Leptin immunoreactivity was determined by RIA in 15-min collected juice from the stomach as described in Materials & Methods. Data are expressed as the mean±SEM of n = 6 in control group and n = 5 in each other group. *P<0.05 and ***P<0.01 vs CTRL.

Figure 9

doi: https://doi.org/10.1371/journal.pone.0007935.g009