IL-6 Deficiency Attenuates Murine Diet-Induced Non-Alcoholic Steatohepatitis
Figure 5
Effects of IL-6 deficiency on MCD diet-induced changes in liver gene expression.
The mRNA levels of PPAR-γ1, 2 (A), TGF-β (B), MCP-1 (C), and F4/80 (D) were measured by quantitative RT-PCR and normalized to the level of HPRT mRNA. Results are expressed as the percentage of the levels found in WT mice fed a normal diet. Each determination was performed in duplicate. Data are means±SEM; the number of animals is indicated into each column. Asterisks denote significant differences (* p<0.05, ** p<0.01, *** p<0.001) between mice of different genotypes on the same diet (when indicated above the line) or between different diets for the same genotype (when indicated above the columns). Further symbols ($ p<0.05, $$ p<0.01) indicate differences between IL-6−/− and WT mice on a normal diet.