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Relationships between Hematopoiesis and Hepatogenesis in the Midtrimester Fetal Liver Characterized by Dynamic Transcriptomic and Proteomic Profiles

Figure 1

Development-associated changes in tissue expression patterns and the biological functions of the four dynamic types of liver genes.

(A) The four dynamic types of liver genes with differentially expressed mRNA during E11.5, E14.5, E15.5, and 3 dpp. All the 1,428 differentially expressed genes exhibited mRNA changes between any two developmental stages that exceeded 2 fold. (B) Hierarchical clustering of biological functions for the four dynamic types. The biological functions are annotated by PANTHER. The ratio of each function in a type is expressed relative to its median ratio across all the four types and is depicted according to a color scale shown at the bottom. Red and green indicate the ratio of each function above and below the median, respectively. The magnitude of deviation from the median is represented by the color saturation. (C) Tissue expression patterns of the four dynamic types, shown for both the transcriptome and proteome. The three axes represent the ratio of the tissue-enriched genes in liver, hematopoietic tissue, and embryonic tissue. Gene tissue distribution information was annotated by GeneAtlas.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0007641.g001