Enteric Neural Crest Differentiation in Ganglioneuromas Implicates Hedgehog Signaling in Peripheral Neuroblastic Tumor Pathogenesis
Figure 2
Enteric NC markers CGRP (A), and GFAP (B) were expressed more strongly in GN than NB.
Antibodies to CGRP labeled rare cells (blue arrowheads) in NB and adrenal medulla (Ad), while labeling neurons (blue arrowheads) and processes (blue arrows) throughout both GNs and enteric ganglia (gut). Antibodies to GFAP labeled stromal cords in NB and rare adrenal medullary cells (blue arrowheads). In contrast, labeling was intense and widespread in GN and in ganglia of the gut (outlines by dotted white lines).