Effect of DLK1 and RTL1 but Not MEG3 or MEG8 on Muscle Gene Expression in Callipyge Lambs
Figure 1
Organization of the DLK1-DIO3 gene cluster in mammals.
The relative positions of the maternal non-coding RNA genes and paternal protein coding genes are based on the bovine chromosome 21 sequence contig NW_001494068. The genes are shaded black on the parent-of-origin chromosome to indicate their allele-specific expression. The protein coding genes are expressed from the paternal allele (pat) and the non-coding RNA are expressed from the maternal allele (mat). The causative mutation (SNPCLPG) for the callipyge phenotype lies in the intergenic region between DLK1 and MEG3. The black diamond indicates the approximate position of Affymetrix probe Bt18078.1.S1_at. The presence of C/D snoRNA and most miRNA have been detected in the bovine genome sequence but have not been confirmed in sheep.