A Comprehensive Microarray-Based DNA Methylation Study of 367 Hematological Neoplasms
Figure 6
Most genes showing hypomethylation of promoter regions in T-PLL are associated with increased gene expression.
(A) Genes hypomethylated in T-PLL as compared with CD3+ normal T cells. Genes are arranged alphabetically. (B) Gene expression of hypomethylated genes in T-PLL cases as compared to CD3+ normal T cells. Genes are arranged according to their differential expression in T-PLL vs. normal controls (most upregulated genes on the top). Genes showing at least a 0.5 fold increase (in log2 scale), no expression changes or a 0.5 fold decrease are marked with orange, grey or green lines, respectively, on the right of the heatmap. The CpG content of the promoter sequences of the genes presented is depicted as color code in a separate column (low CpG content (LCP) = blue, intermediate CpG content (ICP) = yellow, high CpG content (HCP) = red, white = data not available). Two of the T-PLL cases (case 1 and case 3) have been studied both by DNA methylation and gene expression profiling. The normal CD3+ T cells used for DNA methylation and gene expression profiling were different. * Gene expression data have been published before by Dürig et al. [26]