Utilization of Genomic Signatures to Identify Phenotype-Specific Drugs
Figure 1
Strategy of a gene expression signature-based drug screen.
A gene expression signature that reflects a clinical/biological phenotype is used to profile the NCI-60 panel to identify cells that exhibit the phenotype of interest. The predicted probability for the signature is correlated against the sensitivity to over 40,000 (21,603 after filtering) compounds to identify compounds that appear to be effective in cells exhibiting the phenotype.