A Nanoconjugate Apaf-1 Inhibitor Protects Mesothelial Cells from Cytokine-Induced Injury
Figure 3
Inflammatory cytokines retard remesothelization.
A) Wound healing in HPMC. Contrast phase microscopy. Cells were preincubated with caspase inhibitor or vehicle and cultured in presence of proinflammatory TNFα/IFNγ or control media. Original magnification 20×. B) Quantification of wound healing as number of HPMC cells filling the denuded area (cells/mm2). In presence of cytokines there is delayed wound healing that is not improved by zVAD.* p<0.03 control vs. TNFα/IFNγ and control vs TNFα/IFNγ/zVAD. Mean±SEM of 5 different experiments.