The Impact of IPTi and IPTc Interventions on Malaria Clinical Burden – In Silico Perspectives
Figure 1
Model representing the dynamics of malaria transmission in a population under treatment.
The model is an extension of the model in [27]. The compartments represent the following epidemiological classes: S = completely susceptible individuals, either newborns, or individuals that have lost protection conferred in R, or have cleared drugs from the bloodstream while in ST; I1 = clinical malaria resulting from an infection in a completely susceptible individual or after drug clearance from I1T; R = individuals that recovered from infections I1 or I2 or that have cleared the drugs from circulation while in RT, and are clinically immune, developing a mild form of disease if exposed. I2 = mild/asymptomatic disease resulting from exposure of recovered individuals or drug clearance while in I2T. ST = completely susceptible individuals that were treated, have lost immunity conferred in RT, or failed to build up their immunity after an infection. I1T = severe disease resulting from an infection in a treated susceptible individual, or treated while in I1. RT = individuals that recovered from infections I1T or I2T and acquired clinical protection, or where treated while in R. I2T = mild/asymptomatic disease resulting from exposure of RT individuals or treated while in I2. The parameters are described in Table 1. A percentage of infants (according to programme coverage) depicted as γ is discretely moved to the corresponding treated classes, at specific ages.