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In Vivo Delta Opioid Receptor Internalization Controls Behavioral Effects of Agonists

Figure 1

Delta agonists differentially internalize DOR-eGFP in primary neurons.

Striatal and hippocampal primary neurons were treated for 60 minutes with Met-enkephalin, SNC80 or ARM390. (A) Representative images of hippocampal neurons treated with 100 nM of agonists are shown. Scale bar is 12 µm. (B) Internalized DOR-eGFP co-localized with lysosomes. Striatal primary neurons were incubated with Met-enkephalin (100 nM) or SNC80 (100 nM) for 20 or 120 minutes, along with LysoTracker Red DND 99 (300 nM); scale bar is 12 µm.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0005425.g001