The Phytoestrogen Genistein Affects Zebrafish Development through Two Different Pathways
Figure 6
(A) Alignment of a part of the ligand binding domain of several vertebrate ERs. The two main amino acids involved in the binding of genistein are underlined. Blue for human ERβ-like amino acids and pink for human ERα-like amino acids. (B) modelling of the ligand binding pocket of estrogen receptors in presence of genistein. The sequences used for the modelling were from human (hERα and hERβ) or from zebrafish (zfERα, zfERβ-A, zfERβ-B). The α-type amino acids are boxed in blue whereas the β-type amino acids are boxed in red. The non variable amino acids are not boxed. Numbering refers to each receptor.