Concordance in a World without a Gold Standard: A New Non-Invasive Methodology for Improving Accuracy of Fibrosis Markers
Figure 2
Associations between three estimates of liver fibrosis: FibroTest, liver stiffness measurements and fibrosis stage at biopsy, in 266 patients with recommended criteria.
Each point represents the result of biopsy stage using METAVIR scoring system: white circle F0 (no fibrosis), light grey triangle F1 (portal fibrosis), grey square F2 (few septa), light black pentagon F3 (many septa) and dark black hexagon F4 (cirrhosis). These points are distributed according to FibroTest value on the vertical axis and liver stiffness measurements on horizontal axis. The first horizontal line is the FibroTest cutoff (0.48) for stage F2, the second (0.73) for F4. The first vertical line is the stiffness cutoff (8.8 kPa) for stage F2, the second (14.5 kPa) for F4.