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In Vitro Cellular Adaptations of Indicators of Longevity in Response to Treatment with Serum Collected from Humans on Calorie Restricted Diets

Figure 1

Proliferation of HepG2 cells cultured with serum from FEAST and CALERIE participants.

HepG2 cells were cultured in 96 well culture plates in culture media supplemented with 10% human serum. After 48 hours in culture, differences in the proliferation of HepG2 cells in serum collected at day 21 from FEAST participants or after 3 months from CALERIE participants were compared to the proliferation of cells cultured in serum from the same participants collected on baseline day. Graph shows % proliferation relative to baseline of cells cultured in serum collected from participants of the (A) FEAST study (n = 11) and (B) CALERIE (n = 9 for C group, n = 11 for CR group, n = 11 for CREX group) study. * = statistically significant p = 0.032).

Figure 1

doi: https://doi.org/10.1371/journal.pone.0003211.g001