Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features
Figure 4
Cluster analysis of genetic aberrations in the different molecular subtypes identified with array CGH.
Array probes were grouped together according to their position in distinct cytobands. Cytobands were then scored in each tumor as gained (+1, red), lost (−1, green), or unchanged (0, white), based on the array CGH data for all probes in a particular cytoband region. Subsequently, these cytoband data for gain, loss or no change were clustered using an unsupervised one-way hierarchical clustering. This was done for each molecular subtype separately.