Hepatotoxin-Induced Changes in the Adult Murine Liver Promote MYC-Induced Tumorigenesis
Figure 1
Examining the Impact of DDC and CCl4 Damage on MYC-Induced HCC.
(A) Schematic of the liver lobule illustrating that DDC causes liver damage associated with the emergence and proliferation of oval cells in the periportal area of the hepatic lobule, while CCl4 causes damage associated with the destruction of hepatocytes near the central vein and triggers mature hepatocytes to proliferate. (B) Schematic of experimental design. Eight different cohorts of mice were monitored for tumorigenesis. MYC was activated (MYC ON) or kept inactive (MYC OFF) in mice: at birth, in 6–10 week old adult, in 6–10 w old adult mice treated with DDC, or in 6–10 w old adult mice treated with CCl4. Mice were sacrificed when moribund with tumor burden.