Immunogenecity of Modified Alkane Polymers Is Mediated through TLR1/2 Activation
Figure 5
Modified alkane polymers induce activation of TLR-1 and TLR-2 signaling pathways.
a) Luciferase activity expressed by human TLR1/2, TLR2, TLR3 and TLR4 stable HEK 3T3 transfectant (pNF-κB-LUC Stratagene). Cells were left untreated or treated for a different time period with 50 μg/ml of unPE, mPE or pre and post implant PE and respective positive controls; PGN(10 μg/ml) for TLR1/2 and TLR2, Poly (I∶C)(1 μg/ml) for TLR3 and LPS (10 μg/ml) for TLR4.