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A High Through-Put Reverse Genetic Screen Identifies Two Genes Involved in Remote Memory in Mice

Figure 2

Primary screening of 54 mutant strains identifies 4 putative remote memory mutants.

Combined mean z-scores for freezing and activity suppression ratios are shown for all 54 mutant strains for a) baseline, b) immediate memory, c) remote memory and d) short-term memory results. The white shaded box denotes values that fall within +/−1.0 standard deviation from the normal population. Mean z-scores for the αCaMKII+/− mutant mice (see also Supplemental Figure S1 and Text S1) are shown in red for comparison. The asterisks denote putative remote memory mutants. BL = Baseline; IM = immediate memory; RM = 7 day memory; STM = short-term memory.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0002121.g002