Patterns of Neurogenesis and Amplitude of Reelin Expression Are Essential for Making a Mammalian-Type Cortex
Figure 8
A role of Reelin-positive cells in the developing vertebrate pallium.
(Left) Without Reelin-positive cells, radial glial cells (RG) extend fibers in multiple orientations. Neurons migrate independently, and exhibit a multi-polar shape (a, b). (Right) In the presence of Reelin-expressing cells at the pial surface (magenta), RG fibers are directed toward the source of Reelin. Migrating neurons shorten their own fibers for translocation (c) or attach to RG fibers for locomotion (d). Neurons exhibit a polarized shape during and after migration (e).