Transcriptional Profiling of Non-Small Cell Lung Cancer Cells with Activating EGFR Somatic Mutations
Figure 5
Expression signature that distinguishes two types of EGFR mutations.
A 194-gene signature present in EGFR-mutant but not EGFR–wild-type cell lines distinguishes L858R (P.M. [point mutation]) from Δ746–750 (deletion). Cells were treated with (+) or without (−) gefitinib. A partial list of the genes that are differentially expressed in the two groups is indicated on the right.