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Mathematical Identification of Critical Reactions in the Interlocked Feedback Model

Figure 2

A schematic diagram of the interlocked feedback system in the Drosophila circadian clock.

In the real biochemical reactions, the binding of PER-P:TIM to dCLK:CYC suppresses the transcription for PER and TIM and activates the transcription for dCLK. In this map, PER-P:TIM directly suppresses the transcription of PER and TIM and activates the transcription for dCLK. “:” and “-” indicate binding complexes and modification, respectively.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0001103.g002