Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature
Fig 4
Peripheral blood cytotoxicity and ISG signatures are associated with CTL/NK cells and monocytes/monocyte-like macrophages, respectively.
(A) Median of MCP-counter abundance scores for cell types that were differentially enriched between CL patients and HS. NK cells, cytotoxic lymphocytes (CTL), monocytes and macrophage/monocytes were differentially enriched by Wilcoxon rank-sum test, P<0.05. (B) A correlation matrix between the MCP-counter abundance scores and the expression of the 51 genes overexpressed in the blood of CL patient samples, in log2 CPM. Spearman’s rho (ρ) correlation coefficient ranges from 1 (red) to -1 (yellow). Correlations where P<0.05 are not represented in the plot (blank spots).