Epigenetic regulation of defense genes by histone deacetylase1 in human cell line-derived macrophages promotes intracellular survival of Leishmania donovani
Fig 7
Mechanism of action of siRNA mediated HDAC1 down-regulation and its impact on intracellular L. donovani A: Infection with L. donovani (LD), increases histone deacetylase (HDAC) levels which further leads to decrease in expression of the antimicrobial factors. Thereby facilitating the establishment of parasite infection within the host cells. B: Transfection of host cells with HDAC1-siRNA, leads to reduced HDAC1 and reduced deacetylation of histones, facilitating increased transcription of host defense genes and decreased intracellular load of L. donovani.