Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping
Fig 4
Structural presentation of linear epitope elements found in two representative M-domains.
Core residues of each series of overlapping peptides recognized by the antivenom are colored according to the sum of running median scores for the peptide series in a scale from purple to red (largest sum). The rest of the protein backbone is colored blue. Selected residues are labeled for reference to Fig 3. Antivenom antibodies recognize residues in the upper molecular body, while substrate binding is determined by the flexible region in the lower subdomain, and the active site is present between the two subdomains [53]. (A) M-domain from the SVMP P-I, P83512, from B. asper. (B) M-domain from the SVMP P-III, J3SDW8, from C. adamanteus.