Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems
Fig 8
Ovary alterations in adult female worms treated with PHX.
Representative confocal laser scanning microscope images of adult female ovaries. S. mansoni worm couples were treated for 3 and 6 days with DMSO (a, b) or different doses of PHX (c-h) for 3 and 6 days as indicated and stained with carmine red. Immature oocytes (io), mature oocytes (mo), receptaculum seminis (rs) are indicated. Scale bars = 50 μm (a-c), and 25 μm in all other PHX treated samples (d-h) are shown.