Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems
Fig 7
Testis degeneration in adult male worms treated with PHX—Transmission electron microscopy.
Representative images of adult male testis. S. mansoni worm couples were treated with DMSO (A-C) or PHX (5 μM) (D-F) for 48 hours as indicated. Membranous bodies (MB), basal lamina (BL), flagellum (Fl), spermatozoa (Sp), acrosome (Acr), lipid droplets (LD), nucleus (Nu), circular muscle (CM), axonema (Ax). Yellow and red arrows in low magnification panels (A, D) point out high magnification fields of view of B, C and E, F respectively. Scale bar = 500 nm.